The details of the IRB/oversight body that provided approval or exemption for the research described are given below:Īpproval for this study was provided by the institutional review board of both Hennepin County Medical Center. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. This study is funded by an MN State SCI/TBI grant from the Minnesota Office of Higher Education. Licensed optimization IP from the University of Minnesota. Darrow hold equity in and serve as officers for Stim Sherpa, which has We conclude that SCS restores muscle movements and muscle synergies that are distinct from healthy, able-bodied controls. Lastly, we found that the muscle synergies were restored with SCS, supporting the neural hypothesis of muscle synergies. We also found that over the follow-up sessions, the muscle synergy structure of the SCI participants became more defined, and the number of synergies decreased over time, indicating improved coordination between the muscle groups. We found that the complexity of muscle activity is immediately reduced with SCS in the SCI participants. Muscle activity complexity was computed with Higuchi Fractal Dimensional analysis (HFD), and muscle synergies were estimated using non-negative matrix factorization (NNMF) in six participants with AIS A chronic SCI. In addition, competition exists between the task and neural origin hypotheses underlying muscle synergies, and this analysis in humans with motor and sensory complete chronic injury provided an opportunity to test these hypotheses. Using a structured surface electromyogram based (sEMG) task with and without SCS during the Epidural Stimulation After Neurological Damage (ESTAND) study in participants with chronic, motor and sensory complete SCI, we investigated muscle activity complexity and muscle synergies to better characterize neuro-muscular control. Multiple studies have corroborated restored volitional motor control after motor-complete spinal cord injury (SCI) through the use of spinal cord stimulation (SCS/eSCS) but rigorous quantitative descriptions have been lacking.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |